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KMID : 1225720120040060351
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Allergy, Asthma & Immunology Research : AAIR
2012 Volume.4 No. 6 p.351 ~ p.356
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Elevated Serum Levels of IL-21 in Kawasaki Disease
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Bae Yon-Jung
Kim Mi-Hyun
Lee Hae-Yong
Uh Young
Namgoong Mee-Kyung
Cha Byung-Ho
Chun Jin-Kyong
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Abstract
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Purpose: The serum level of immunoglobulin (Ig)E has been reported to be elevated in patients with Kawasaki disease (KD). We investigated whether interleukin (IL)-21, rather than IL-4, could be related to elevated serum levels of IgE in KD.
Methods: Sera from 48 patients with KD and 12 controls with high fever were collected to determine the level of IgE using an immunoassay system and the levels of IL-4 and IL-21 were determined using enzyme-linked immunosorbent assay kits.
Results: The median IL-21 level of KD patients was significantly elevated, at 499.5 pg/mL (range: <62.5-1,544 pg/mL), whereas that of controls was <62.5 pg/mL (<62.5-825 pg/mL; P<0.001). The median IL-4 level of KD patients was not elevated (4.0 pg/mL; 2.1-7.6 pg/mL). The median level of total IgE in KD patients was 58.0 IU/mL (5-1,109 IU/mL). No statistically significant correlation was found between IL-21 and total IgE levels (Spearman’s R=0.2; P=0.19).
Conclusions: Patients with KD have elevated levels of IL-21 in the serum. IL-21 may play a role in the pathogenesis of KD.
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KEYWORD
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Interleukin-21, immunoglobulin E, mucocutaneous lymph node syndrome
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